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Single‐reaction multi‐antigen serological test for comprehensive evaluation of SARS‐CoV‐2 patients by flow cytometry

Authors
  • Cáceres‐Martell, Yaiza1
  • Fernández‐Soto, Daniel1
  • Campos‐Silva, Carmen1
  • García‐Cuesta, Eva M.1
  • Casasnovas, Jose M1
  • Navas‐Herrera, David2
  • Beneítez‐Martínez, Alexandra2
  • Martínez‐Fleta, Pedro3
  • Alfranca, Arantzazu3, 4
  • Sánchez‐Madrid, Francisco3, 4
  • Escudero‐López, Gabriela4
  • Vilches, Carlos4
  • Jara‐Acevedo, Ricardo2
  • Reyburn, Hugh T.1
  • Rodríguez‐Frade, José M.1
  • Valés‐Gómez, Mar1
  • 1 National Centre for Biotechnology, CNB‐CSIC, Spain , (Spain)
  • 2 S.L. Salamanca, Spain , (Spain)
  • 3 Hospital Universitario La Princesa IIS‐IP, Spain , (Spain)
  • 4 Instituto de Investigación Sanitaria Puerta de Hierro‐Segovia de Arana, Spain , (Spain)
Type
Published Article
Journal
European Journal of Immunology
Publisher
Wiley (John Wiley & Sons)
Publication Date
Aug 19, 2021
Identifiers
DOI: 10.1002/eji.202149319
PMID: 34358329
PMCID: PMC8420214
Source
PubMed Central
Keywords
Disciplines
  • Immunity to infection
  • Short Communication
  • Clinical
License
Unknown
External links

Abstract

Magnetic fluorescent beads coated with different SARS‐CoV‐2 antigens can be mixed to test simultaneously for antibodies present in patient plasma in highly multiplexed flow cytometry‐based assays. This sensitive method allows identification, in a single reaction, of several Ig‐isotypes and specificities, revealing differential responses between COVID‐19 patients.

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