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Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection

Authors
  • Xie, Xuemei1, 2, 3, 4
  • Shi, Qiang5
  • Wu, Peng1
  • Zhang, Xiaoyu1, 2, 3, 4
  • Kambara, Hiroto2, 3, 4
  • Su, Jiayu2, 3, 4, 5
  • Yu, Hongbo6, 7
  • Park, Shin-Young2, 3, 4
  • Guo, Rongxia1
  • Ren, Qian1
  • Zhang, Sudong1
  • Xu, Yuanfu1
  • Silberstein, Leslie E.2, 3, 4
  • Cheng, Tao1
  • Ma, Fengxia1
  • Li, Cheng5
  • Luo, Hongbo R.2, 3, 4
  • 1 Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China , Tianjin (China)
  • 2 Harvard Medical School, Boston, MA, USA , Boston (United States)
  • 3 Boston Children’s Hospital, Boston, MA, USA , Boston (United States)
  • 4 Dana-Farber/Harvard Cancer Center, Boston, MA, USA , Boston (United States)
  • 5 Peking University, Beijing, China , Beijing (China)
  • 6 VA Boston Healthcare System, Boston, MA, USA , Boston (United States)
  • 7 Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA , Boston (United States)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Jul 27, 2020
Volume
21
Issue
9
Pages
1119–1133
Identifiers
DOI: 10.1038/s41590-020-0736-z
Source
Springer Nature
License
Yellow

Abstract

Luo and colleagues use single-cell RNA sequencing to provide a comprehensive transcriptional landscape of neutrophil maturation, function and fate decision in their steady state and during bacterial infection.

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