Affordable Access

deepdyve-link
Publisher Website

Single-Cell Sequencing of Peripheral Mononuclear Cells Reveals Distinct Immune Response Landscapes of COVID-19 and Influenza Patients

Authors
  • Zhu, Linnan1, 2
  • Yang, Penghui3
  • Zhao, Yingze4
  • Zhuang, Zhenkun1, 2, 5
  • Wang, Zhifeng1
  • Song, Rui6
  • Zhang, Jie4
  • Liu, Chuanyu1
  • Gao, Qianqian1
  • Xu, Qumiao1
  • Wei, Xiaoyu1, 7
  • Sun, Hai-Xi1, 2
  • Ye, Beiwei4
  • Wu, Yanan4
  • Zhang, Ning8
  • Lei, Guanglin3
  • Yu, Lingxiang3
  • Yan, Jin3
  • Diao, Guanghao3
  • Meng, Fanping3
  • And 24 more
  • 1 BGI-Shenzhen, 518103 Shenzhen, China
  • 2 China National GeneBank, BGI-Shenzhen, 518120 Shenzhen, China
  • 3 Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, 100039 Beijing, China
  • 4 NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 102206 Beijing, China
  • 5 School of Biology and Biological Engineering, South China University of Technology, 510006 Guangzhou, China
  • 6 Center of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, 100015 Beijing, China
  • 7 BGI Education Center, University of Chinese Academy of Sciences, 518083 Shenzhen, China
  • 8 CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, 100101 Beijing, China
  • 9 Northwest A&F University, Yangling, 712100 Shanxi, China
  • 10 BGI-GenoImmune, BGI-Shenzhen, 4300794 Wuhan, China
Type
Published Article
Journal
Immunity
Publication Date
Jul 19, 2020
Volume
53
Issue
3
Pages
685–696
Identifiers
DOI: 10.1016/j.immuni.2020.07.009
PMID: 32783921
PMCID: PMC7368915
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Unknown

Abstract

COVID-19 and influenza are both respiratory infections with cytokine release syndrome. Zhu et al. use single-cell RNA sequencing of longitudinally collected PBMCs in both patients to reveal distinct immune response landscapes of the two diseases and identify virus-specific cell composition and immune response pathways.

Report this publication

Statistics

Seen <100 times