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Single-cell landscape of immunological responses in patients with COVID-19

Authors
  • Zhang, Ji-Yuan1
  • Wang, Xiang-Ming2
  • Xing, Xudong3
  • Xu, Zhe1
  • Zhang, Chao1
  • Song, Jin-Wen1
  • Fan, Xing1
  • Xia, Peng1
  • Fu, Jun-Liang1
  • Wang, Si-Yu1
  • Xu, Ruo-Nan1
  • Dai, Xiao-Peng1
  • Shi, Lei1
  • Huang, Lei1
  • Jiang, Tian-Jun1
  • Shi, Ming1
  • Zhang, Yuxia4
  • Zumla, Alimuddin5, 6
  • Maeurer, Markus7, 8
  • Bai, Fan2
  • And 1 more
  • 1 Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing, China , Beijing (China)
  • 2 Peking University, Beijing, China , Beijing (China)
  • 3 School of Life Sciences, Tsinghua University, Beijing, China , Beijing (China)
  • 4 Guangzhou Medical University, Guangzhou, Guangdong, China , Guangzhou (China)
  • 5 University College London, London, UK , London (United Kingdom)
  • 6 University College London Hospitals NHS Foundation Trust, London, UK , London (United Kingdom)
  • 7 Immunotherapy Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal , Lisbon (Portugal)
  • 8 University of Mainz, Mainz, Germany , Mainz (Germany)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Aug 12, 2020
Volume
21
Issue
9
Pages
1107–1118
Identifiers
DOI: 10.1038/s41590-020-0762-x
Source
Springer Nature
License
Yellow

Abstract

Severe COVID-19 is characterized—among other things—by a hyperinflammatory state. Wang and colleagues describe the single-cell transcriptional landscape of moderate, severe and convalescent cases of patients with COVID-19.

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