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Single section Western blot: improving the molecular diagnosis of the muscular dystrophies.

Authors
Type
Published Article
Journal
Neurology
1526-632X
Publisher
Ovid Technologies (Wolters Kluwer) - American Academy of Neurology
Publication Date
Volume
61
Issue
1
Pages
93–97
Identifiers
PMID: 12847163
Source
Medline
License
Unknown

Abstract

Single section Western blot (SSWB) is an improved methodology for molecular diagnosis of the muscular dystrophies, requiring only a single 8-microm muscle biopsy cryosection for the simultaneous analysis of multiple disease candidates. The authors demonstrate that SSWB can be used for diagnosis of dystrophinopathies, to identify haploinsufficiency in autosomal dominant laminopathy, and as a tool to distinguish between primary and secondary immunohistochemical abnormalities in limb-girdle muscular dystrophy type 2B.

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