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Single-scattering spectroscopy for the endoscopic analysis of particle size in superficial layers of turbid media.

Authors
  • Amelink, Arjen
  • Bard, Martin P L
  • Burgers, Sjaak A
  • Sterenborg, Henricus J C M
Type
Published Article
Journal
Applied optics
Publication Date
Jul 01, 2003
Volume
42
Issue
19
Pages
4095–4101
Identifiers
PMID: 12868852
Source
Medline
License
Unknown

Abstract

We report on the development of an optical-fiber-based diagnostic tool that is sensitive to single-scattering events close to the fiber-optic probe tip. By using a single fiber to deliver and detect white light we optimised the detection probability of singly scattered photons from small depths. The sampling depth of this delivery-and-collection fiber was investigated by use of a tissue phantom. We found that for our phantom 90% of the single-scattering signal in the delivery-and-collection fiber originated from less than 200 microm from the fiber tip. The contribution of multiply scattered light from a greater depth to the signal was measured with an additional collection fiber. Several tissue phantoms demonstrated our fiber-optic probes sensitivity to light scattering from superficial layers of tissue and thereby its potential to detect superficial precancerous epithelial lesions.

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