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Single-scattering spectroscopy for the endoscopic analysis of particle size in superficial layers of turbid media.

Authors
Type
Published Article
Journal
Applied optics
Publication Date
Volume
42
Issue
19
Pages
4095–4101
Identifiers
PMID: 12868852
Source
Medline
License
Unknown

Abstract

We report on the development of an optical-fiber-based diagnostic tool that is sensitive to single-scattering events close to the fiber-optic probe tip. By using a single fiber to deliver and detect white light we optimised the detection probability of singly scattered photons from small depths. The sampling depth of this delivery-and-collection fiber was investigated by use of a tissue phantom. We found that for our phantom 90% of the single-scattering signal in the delivery-and-collection fiber originated from less than 200 microm from the fiber tip. The contribution of multiply scattered light from a greater depth to the signal was measured with an additional collection fiber. Several tissue phantoms demonstrated our fiber-optic probes sensitivity to light scattering from superficial layers of tissue and thereby its potential to detect superficial precancerous epithelial lesions.

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