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Single nucleotide polymorphisms in microRNAs action as biomarkers for breast cancer.

Authors
  • Nguyen, Thanh Thi Ngoc1, 2
  • Tran, Minh Thi Hong1, 2
  • Nguyen, Vy Thi Lan1, 2
  • Nguyen, Uyen Doan Phuong1, 2
  • Nguyen, Giang Dien Thanh1, 2
  • Huynh, Luan Huu1, 2
  • Nguyen, Hue Thi1, 2
  • 1 Department of Physiology and Animal Biotechnology, Faculty of Biology and Biotechnology, University of Science, Ho Chi Minh City Vietnam.
  • 2 Vietnam National University, Ho Chi Minh City Vietnam.
Type
Published Article
Journal
Turkish journal of biology = Turk biyoloji dergisi
Publication Date
Jan 01, 2020
Volume
44
Issue
5
Pages
284–294
Identifiers
DOI: 10.3906/biy-2004-78
PMID: 33110366
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

MicroRNAs (miRNAs) have been recently described as small noncoding RNAs that are involved in numerous crucial physiological processes, such as cell cycles, differentiation, development, and metabolism. Thus, dysregulation of these molecules could lead to several severe disorders, including breast cancer (BC). Ongoing investigations in malignant growth diagnostics have distinguished miRNAs as promising disease biomarkers. As with any other mRNAs, single nucleotide polymorphisms (SNPs) in DNA sequence encoding for miRNA (miR-SNPs) indeed lead to potential changes in the function of miRNA. In this study, miR-SNPs located in different miRNA sequence regions, which have been associated with BC in different ways, and the potential mechanisms of how these miR-SNPs develop the risk of the disease were discussed. Copyright © 2020 The Author(s).

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