Affordable Access

Single- and multistep resistance selection studies on the activity of retapamulin compared to other agents against Staphylococcus aureus and Streptococcus pyogenes.

Authors
  • 1
Type
Published Article
Journal
Antimicrobial Agents and Chemotherapy
0066-4804
Publisher
American Society for Microbiology
Publication Date
Volume
50
Issue
2
Pages
765–769
Identifiers
PMID: 16436741
Source
Medline

Abstract

Retapamulin had the lowest rate of spontaneous mutations by single-step passaging and the lowest parent and selected mutant MICs by multistep passaging among all drugs tested for all Staphylococcus aureus strains and three Streptococcus pyogenes strains which yielded resistant clones. Retapamulin has a low potential for resistance selection in S. pyogenes, with a slow and gradual propensity for resistance development in S. aureus.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments
F