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Single- and multistep resistance selection studies on the activity of retapamulin compared to other agents against Staphylococcus aureus and Streptococcus pyogenes.

Authors
  • Kosowska-Shick, Klaudia1
  • Clark, Catherine
  • Credito, Kim
  • McGhee, Pamela
  • Dewasse, Bonifacio
  • Bogdanovich, Tatiana
  • Appelbaum, Peter C
  • 1 Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033, USA.
Type
Published Article
Journal
Antimicrobial agents and chemotherapy
Publication Date
February 2006
Volume
50
Issue
2
Pages
765–769
Identifiers
PMID: 16436741
Source
Medline
License
Unknown

Abstract

Retapamulin had the lowest rate of spontaneous mutations by single-step passaging and the lowest parent and selected mutant MICs by multistep passaging among all drugs tested for all Staphylococcus aureus strains and three Streptococcus pyogenes strains which yielded resistant clones. Retapamulin has a low potential for resistance selection in S. pyogenes, with a slow and gradual propensity for resistance development in S. aureus.

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