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Single-molecule detection sensitivity using planar integrated optics on a chip.

Authors
Type
Published Article
Journal
Optics Letters
Publisher
The Optical Society
Volume
31
Issue
14
Pages
2136–2136
Source
UCSC Bioengineering biomedical-ucsc
License
Unknown

Abstract

We present a fully planar integrated optical approach to single-molecule detection based on microfabricated planar networks of intersecting solid and liquid-core waveguides. We study fluorescence from dye molecules in liquid-core antiresonant reflecting optical waveguides, and demonstrate subpicoliter excitation volumes, parallel excitation through multiple pump waveguides, and single-molecule detection sensitivity. Integrated silicon photonics combined with single-molecule detection in solution create a compact, robust, and sensitive platform that has applications in numerous fields ranging from atomic physics to the life sciences.

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