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Single doses of THC and cocaine decrease proficiency of impulse control in heavy cannabis users.

Authors
  • van Wel, J H P
  • Kuypers, K P C
  • Theunissen, E L
  • Toennes, S W
  • Spronk, D B
  • Verkes, R J
  • Ramaekers, J G
Type
Published Article
Journal
British Journal of Pharmacology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Dec 01, 2013
Volume
170
Issue
7
Pages
1410–1420
Identifiers
DOI: 10.1111/bph.12425
PMID: 24106872
Source
Medline
Keywords
License
Unknown

Abstract

Heavy cannabis users display impairments in a broad range of neuropsychological domains during THC intoxication. Impairments observed in psychomotor tasks, but not in impulsivity tasks, appeared smaller in magnitude as compared with those previously reported in occasional cannabis users. Heavy cannabis users were sensitive to the stimulating and inhibitory effects of cocaine on psychomotor function and impulsivity respectively. The reduction in proficiency in impulse control may put drug users at increased risk of repeated drug use and addiction.

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