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A single dose comparison of piretanide and bumetanide in congestive cardiac failure.

Authors
  • Homeida, M
  • Roberts, C J
  • Dombey, S L
Type
Published Article
Journal
British journal of clinical pharmacology
Publication Date
Aug 01, 1979
Volume
8
Issue
2
Pages
173–178
Identifiers
PMID: 385025
Source
Medline
License
Unknown

Abstract

1 This study has compared the diuresis produced by a single oral administration of 6 mg piretanide, 9 mg piretanide and 1 mg bumetanide in a group of nine patients with cardiac failure using a balanced randomized design. 2 The natriuresis and kaliuresis produced in the first 6 h after administration of piretanide 9 mg and bumetanide 1 mg were similar. Piretanide 6 mg produced a lesser response. 3 There was evidence of sodium and water conservation following the diuresis for up to 48 h with all three treatments. 4 The patterns of urate and calcium excretion were similar for the two diuretics.

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