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A single amino acid substitution (Trp(666)-->Ala) in the interbox1/2 region of the interleukin-6 signal transducer gp130 abrogates binding of JAK1, and dominantly impairs signal transduction.

Authors
Type
Published Article
Journal
The Biochemical journal
Publication Date
Volume
349
Issue
Pt 1
Pages
261–266
Identifiers
PMID: 10861237
Source
Medline

Abstract

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