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A single administration of LFA-1 antibody confers prolonged allograft survival.

Authors
  • Talento, A
  • Nguyen, M
  • Blake, T
  • Sirotina, A
  • Fioravanti, C
  • Burkholder, D
  • Gibson, R
  • Sigal, N H
  • Springer, M S
  • Koo, G C
Type
Published Article
Journal
Transplantation Journal
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Feb 01, 1993
Volume
55
Issue
2
Pages
418–422
Identifiers
PMID: 7679531
Source
Medline
License
Unknown

Abstract

C57BL/6 (B6) thyroid gland transplanted to the left kidney capsule of an allogeneic (BALB/c) host was typically rejected in 14 days. A single administration of 500 micrograms of an antibody to the adhesion molecule, leucocyte function-associated antigen (LFA-1, CD11a), prevented all thyroid allograft rejection for at least 70 days. Fifty percent of the treated recipients retained intact allografts for 470 days. However, the same treatment with anti-CD11a could not protect a sensitized BALB/c mouse from rejecting a second B6 thyroid allograft. Production of donor-specific alloantibodies elicited by allograft rejection was also inhibited in this system. In this transplant model, the Ab therapy is more efficacious than that of FK506, administered daily for 14 days at 15 mg/kg. These results demonstrate the remarkable effect of an anti-LFA-1 antibody in promotion of allograft survival.

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