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Antisynthetase Syndrome: two case report and literature review.

Authors
  • Theilacker, Lívia Regina1
  • Brandão, Fabíola Sampaio1
  • Goulart, Fernanda Velloso1
  • Vaz, João Luiz Pereira2
  • D'Almeida, Luiz Octávio Dias1
  • da Fonseca Salgado, Maria Cecília3
  • 1 Hospital Universitário Gaffrée e Guinle, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
  • 2 Disciplina de Reumatologia, Escola de Medicina e Cirurgia, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
  • 3 Hospital Universitário Gaffrée e Guinle, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil; Disciplina de Reumatologia, Escola de Medicina e Cirurgia, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil. Electronic address: [email protected]
Type
Published Article
Journal
Revista Brasileira de Reumatologia
Publisher
SciELO
Publication Date
2015
Volume
55
Issue
2
Pages
177–180
Identifiers
DOI: 10.1016/j.rbr.2013.05.007
PMID: 25839958
Source
Medline
Keywords
License
Unknown

Abstract

Antissintetase Syndrome (ASS) is characterized by myositis, Raunaud's phenomenon, fever, intertitial lung disease, mechanic's hands and arthropathy associated with the presence of antibodies against tRNA synthetase, especially anti-Jo-1. This article aims to review the literature on ASS and report two cases where the first is a patient with polymyositis who developed subluxation on the proximal interphalangeal joint of bilateral first right finger after a few years of the disease, associated with pulmonary manifestations and positive anti-JO-1. In the second case, we present a patient with dermatomyositis, who developed a subluxation of the two first fingers, anti-Jo1 positive and chest CT changes, but without clinical evidence of pulmonary involvement. These cases reveal the importance of performing early diagnosis. The authors describe two cases of this rare syndrome, emphasizing the severity of interstitial lung disease and arthritis.

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