Affordable Access

Simvastatin reduces MMP-3 level in interleukin 1ß stimulated human chondrocyte culture

Authors
  • P Lazzerini
  • P Capecchi
  • F Nerucci
  • A Fioravanti
  • F Chellini
  • M Piccini
  • S Bisogno
  • R Marcolongo
  • P Laghi
Publication Date
Jul 01, 2004
Source
PMC
Keywords
Disciplines
  • Biology
  • Medicine
License
Unknown

Abstract

Objectives: Matrix metalloproteinases (MMPs) produced by chondrocytes play a role in the development of cartilage degradation in joint diseases. Moreover, inhibition of MMP secretion by macrophages accumulating in arteriosclerotic plaques would account for the plaque stabilising activity of statins in cardiovascular patients. Recently, simvastatin has been shown to inhibit both developing and established collagen induced arthritis in a murine model. We thus decided to investigate the effect of simvastatin on the production of MMP-3 from cultured interleukin (IL)1 stimulated human chondrocytes.

Report this publication

Statistics

Seen <100 times