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Simultaneous study of the biodistribution of radio-yttrium complexed with EDTMP and citrate ligands in tumour-bearing rats.

Authors
  • Beyer, G J
  • Bergmann, R
  • Kampf, G
  • Mäding, P
  • Rösch, F
Type
Published Article
Journal
International Journal of Radiation Applications and Instrumentation Part B Nuclear Medicine and Biology
Publisher
Elsevier
Publication Date
Feb 01, 1992
Volume
19
Issue
2
Pages
201–203
Identifiers
PMID: 1601673
Source
Medline
License
Unknown

Abstract

The influence of the ligands ethylenediaminetetramethylene phosphonic acid (EDTMP) and citrate (CIT) on the biodistribution of radio-yttrium in rats bearing a DS-carcinosarcoma was compared. 88Y-EDTMP and 87Y-CIT were i.v. injected into the same animals. Faster blood clearance and higher renal excretion were observed for the EDTMP-ligand. Of high practical interest is the reduced liver uptake of radio-yttrium (by one order of magnitude) with the EDTMP complex. Since bone and tumour accumulation is only weakly influenced, high tumour-to-liver ratios (up to 14) were observed. We propose to use EDTMP or similar complex ligands for liver blocking when radionuclides like 90Y, 169Yb, 225Ac or other group 3 elements are to be applied in endoradionuclide therapy technique.

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