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Simultaneous monoamine histofluorescence and neuropeptide immunocytochemistry: III. Ontogeny of catecholamine varicosities and neurophysin neurons in the rat supraoptic and paraventricular nuclei.

Authors
  • Khachaturian, H
  • Sladek, J R Jr
Type
Published Article
Journal
Peptides
Publisher
Elsevier
Publication Date
Jan 01, 1980
Volume
1
Issue
1
Pages
77–95
Identifiers
PMID: 7017621
Source
Medline
License
Unknown

Abstract

The ontogeny of the rat supraoptic (SON) and paraventricular (PVN) nuclei was studied using a combined fluorescence-immunocytochemical technique for the simultaneous localization of catecholamines (CA) and neurophysin (NP). NP neurons and CA varicosities were first detected in the SON and PVN at 1 days postcoitus. The development of NP neurons which included increases in immunoreactivity in both nuclei proceeded through fetal and neonatal stages, approaching maturity by 21-28 days postnatal; the maturation of the PVN lagged behind that of the SON. CA varicosities appear to make contact with NP neurons beginning at 21-22 days postnatal adult-like patterns were established. The prenatal dominance of NP stain relative to CA fluorescence may suggest a possible neurotrophic role for magnocellular neurons and/or their products upon ingrowing noradrenergic axons.

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