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Simultaneous fluorescence sensing of Cys and GSH from different emission channels.

Authors
  • Liu, Jing
  • Sun, Yuan-Qiang
  • Huo, Yingying
  • Zhang, Hongxing
  • Wang, Linfang
  • Zhang, Pei
  • Song, Dan
  • Shi, Yawei
  • Guo, Wei
Type
Published Article
Journal
Journal of the American Chemical Society
Publisher
American Chemical Society
Publication Date
Jan 15, 2014
Volume
136
Issue
2
Pages
574–577
Identifiers
DOI: 10.1021/ja409578w
PMID: 24358965
Source
Medline
License
Unknown

Abstract

A chlorinated coumarin-hemicyanine dye with three potential reaction sites was exploited as fluorescent probe for biothiols. The Cys-induced substitution-rearrangement-cyclization, Hcy-induced substitution-rearrangement, and GSH-induced substitution-cyclizatioin cascades lead to the corresponding amino-coumarin, amino-coumarin-hemicyanine, thiol-coumarin with distinct photophysical properties, enabling Cys and GSH to be selectively detected from different emission channels at two different excitation wavelengths.

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