Affordable Access

Simultaneous analysis of nicotine, nicotine metabolites, and tobacco alkaloids in serum or urine by tandem mass spectrometry, with clinically relevant metabolic profiles.

Authors
  • Moyer, Thomas P
  • Charlson, Joel R
  • Enger, Robert J
  • Dale, Lowell C
  • Ebbert, Jon O
  • Schroeder, Darrell R
  • Hurt, Richard D
Type
Published Article
Journal
Clinical chemistry
Publication Date
Sep 01, 2002
Volume
48
Issue
9
Pages
1460–1471
Identifiers
PMID: 12194923
Source
Medline
License
Unknown

Abstract

Nicotine, cotinine, trans-3'-hydroxycotinine, nornicotine, and anabasine can be simultaneously and accurately quantified in either serum or urine by HPLC-tandem mass spectrometry with imprecision <10% at physiologic concentrations and limits of quantification ranging from 0.5 to 5 micro g/L. Knowledge of serum or urine concentrations of these analytes can be used to guide nicotine replacement therapy or to assess tobacco abstinence in nicotine dependency treatment. These measurements are now an integral part of the clinical treatment and management of patients who wish to overcome tobacco dependence.

Report this publication

Statistics

Seen <100 times