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Simulated Moving-Bed Liquid Chromatography with Three Zones for Continuous Desalting of Organic Compounds

Authors
  • Molnár, Z.1
  • Nagy, M.1
  • Hanák, L.1
  • Szánya, T.1
  • Argyelán, J.1
  • 1 Department of Chemical Engineering, University of Veszprém, Veszprém, 158, Hungary , Veszprém
Type
Published Article
Journal
Chromatographia
Publisher
Springer-Verlag
Publication Date
Jul 01, 2004
Volume
60
Issue
Suppl 1
Identifiers
DOI: 10.1365/s10337-004-0355-0
Source
Springer Nature
Keywords
License
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Abstract

Aqueous solutions of DL-β-phenylalanine from a biotechnological process have been desalted by simulated moving bed preparative liquid-chromatography (SMB LC). During the design of a laboratory-scale continuous procedure four kinds of reversed-phase polymeric resin were compared. A suitable adsorbent was chosen and operating conditions were subsequently optimized by using equilibrium data obtained experimentally; productivity of the amino acid was used as the optimization target function. This enabled improvement of operating conditions determined in the first step of the procedure.

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