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SimRare: a program to generate and analyze sequence-based data for association studies of quantitative and qualitative traits.

Authors
  • Li, Biao
  • Wang, Gao
  • Leal, Suzanne M
Type
Published Article
Journal
Bioinformatics (Oxford, England)
Publication Date
Oct 15, 2012
Volume
28
Issue
20
Pages
2703–2704
Identifiers
DOI: 10.1093/bioinformatics/bts499
PMID: 22914216
Source
Medline
License
Unknown

Abstract

SimRare is an interactive program that integrates generation of rare variant genotype/phenotype data and evaluation of association methods using a unified platform. Variant data are generated for gene regions using forward-time simulation that incorporates realistic population demographic and evolutionary scenarios. Phenotype data can be obtained for both case-control and quantitative traits. SimRare has a user-friendly interface that allows for easy entry of genetic and phenotypic parameters. Novel rare variant association methods implemented in R can also be imported into SimRare, to evaluate their performance and compare results, e.g. power and Type I error, with other currently available methods both numerically and graphically.

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