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A simple strategy for the construction of combinatorial cyclic peptoid libraries

Authors
  • Lee, JH
  • Meyer, AM
  • Lim, HS
Publication Date
Dec 01, 2010
Source
[email protected]
Keywords
License
Green
External links

Abstract

Here we describe a simple method that allows for rapid and easy sequence determination of cyclic peptoids. The key idea in this strategy is a post-screening "ring-opening" reaction to convert cyclic peptoids selected from a high-throughput screen into linear peptoids, which can be sequenced by tandem mass spectrometry. Thus, there is no need for encoding. / open / 1 / 1 / 38 / 36 / scie / scopus

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