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A simple Lewis acid induced reaction of phenols with electrophiles: Synthesis of functionalized 4H-chromenes and ortho-benzylphenols

Authors
  • Sreenivasulu, Chinnabattigalla
  • Thadathil, Ditto Abraham
  • Pal, Sumit
  • G, Satyanarayana
Publication Date
Jan 01, 2020
Source
RAIITH
Keywords
License
Unknown

Abstract

Lewis acid ZnCl2 promoted cyclization protocol to 4H-chromenes is accomplished, using readily available phenols and acetophenones as starting materials. Interestingly, the process is feasible under the solvent free environment. Synthesis of a variety of 4H-chromenes have been accomplished using this strategy. In addition, this concept is extended to the synthesis of ortho-benzylphenols by treating phenols either with styrenes or secondary benzylic alcohols.

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