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Similarity of secretory protein I from parathyroid gland to chromogranin A from adrenal medulla.

Authors
  • D V Cohn
  • R Zangerle
  • R Fischer-Colbrie
  • L L Chu
  • J J Elting
  • J W Hamilton
  • H Winkler
Publication Date
Oct 01, 1982
Source
PMC
Keywords
Disciplines
  • Biology
  • Medicine
License
Unknown

Abstract

We have compared the amino acid and carbohydrate compositions, partial amino acid sequences, immunological crossreactivity, and physical properties of secretory protein I of the parathyroid gland and chromogranin A of adrenal gland. This comparison indicates that these proteins are similar molecules. Because secretory protein I is present in secretory granules containing parathormone and is cosecreted with the hormone, and because chromogranin A is contained within chromaffin granules and, likewise, is secreted with the catecholamines, the present observations raise the possibility that this class of protein plays a general role in hormone secretion or storage mechanisms.

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