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Similarities and differences in CD4+ and CD8+ effector and memory T cell generation

Authors
  • Seder, Robert A1
  • Ahmed, Rafi2
  • 1 Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892-3005, USA , Bethesda (United States)
  • 2 Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, 30322, USA , Atlanta (United States)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Sep 01, 2003
Volume
4
Issue
9
Pages
835–842
Identifiers
DOI: 10.1038/ni969
Source
Springer Nature
License
Yellow

Abstract

Naive CD4+ and CD8+ T cells undergo unique developmental programs after activation, resulting in the generation of effector and long-lived memory T cells. Recent evidence indicates that both cell-intrinsic and cell-extrinsic factors regulate memory T cell differentiation. This review compares and contrasts how naive CD4+ and CD8+ T cells make the transition to effector and/or memory cells and discusses the implications of these findings for vaccine development.

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