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There are similarities between rheumatic disease with lung involvement and COVID-19 pneumonia

Authors
  • Williamson, Joseph1
  • Black, Louisa2
  • Black, Anna3
  • Koduri, Gouri4
  • Kelly, Clive5
  • 1 Sheffield University,
  • 2 Walsall Hospital,
  • 3 St Thomas’ Hospital,
  • 4 Southend Hospitals, Prittlewell Chase, UK
  • 5 University of Newcastle Upon Tyne,
Type
Published Article
Journal
Irish Journal of Medical Science
Publisher
Springer International Publishing
Publication Date
Feb 10, 2021
Pages
1–5
Identifiers
DOI: 10.1007/s11845-021-02545-y
PMID: 33564974
PMCID: PMC7872822
Source
PubMed Central
Keywords
License
Unknown

Abstract

Introduction There is considerable overlap between the clinical manifestations of covid-19 pneumonia and the acute interstitial lung disease seen in certain rheumatic disorders. In addition, pulmonary fibrosis is increasingly recognised as a potentially serious consequence of both. Methods This review explores this overlap of clinical features, risk factors and causation, offering insights into the immune mechanisms that contribute to both sets of disorders. Results The therapeutic role of immunosuppression and biologic agents in the treatment of covid-19 is explained in the light of this. Discussion We propose how lessons learned from the insights recently gained into each disorder can improve our insight into immunological mechanisms and application of therapeutic interventions in the other.

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