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Similar effects of treatment with desipramine and electroconvulsive shock on 5-hydroxytryptamine1A receptors in rat brain.

Authors
Type
Published Article
Journal
European Journal of Pharmacology
0014-2999
Publisher
Elsevier
Publication Date
Volume
202
Issue
2
Pages
221–225
Identifiers
PMID: 1839385
Source
Medline

Abstract

The effect of chronic and acute treatment with desipramine (DMI) and electroconvulsive shock (ECS) on 5-hydroxytryptamine1A (5-HT1A) receptors was determined in the cortex and the hippocampus brain regions of rats. We observed that chronic treatment with both DMI and ECS significantly decreased 5-HT1A receptors, as determined by [3H]8-hydroxy-2-(di-n-propylamino)tetralin [( 3H]8-OH-DPAT) binding, in the cortex but not in the hippocampus. Acute treatment with DMI or ECS did not significantly alter the 5-HT1A receptors in the cortex. Neither chronic nor acute treatment influenced KD of [3H]8-OH-DPAT binding in the cortex or hippocampus. These results thus suggest that in contrast to the effects on 5-HT2 receptors, tricyclics as well as ECS produce similar effects on 5-HT1A receptors, suggesting that this site may represent a common site of action for antidepressant treatment.

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