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Silver/silver chloride (Ag/AgCl) nanoparticles synthesized from Azadirachta indica lalex and its antibiofilm activity against fluconazole resistant Candida tropicalis.

Authors
  • Al Aboody, Mohammed Saleh1
  • 1 a Department of Biology, College of Science, Al-Zulfi-, Majmaah University , Majmaah , Riyadh Region , Kingdom of Saudi Arabia. , (Saudi Arabia)
Type
Published Article
Journal
Artificial Cells Nanomedicine and Biotechnology
Publisher
Informa UK (Taylor & Francis)
Publication Date
Dec 01, 2019
Volume
47
Issue
1
Pages
2107–2113
Identifiers
DOI: 10.1080/21691401.2019.1620257
PMID: 31137983
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

In this study, latex of Azadirachta indica was used for the synthesis of silver nanoparticles (AgNP). UV-visible spectroscopy revealed the formation of AgNPs and the absorption band optimized at 442 nm. Fourier transform infrared (FTIR) spectroscopy shows different functional groups (carboxyl, amine and hydroxyl) of biomolecule which are responsible for reduction and capping process. X-ray diffraction (XRD) analysis confirms the nanoparticles are crystalline silver and cubic (AgCl) with face-centered cubic (Ag) types. Electron microscopics (SEM and TEM) were used to characterize the shape and size of the nanoparticles. The anticandidal and antibiofilm activity of AgNPs was using Fluconazole resistant clinical isolate of Candida tropicalis. The new approach of plant-mediated AgNPs synthesis appears to be cost-effective, eco-friendly and easy methods. The synthesized AgNPs considered as a novel and alternative agent to prevent C. tropicalis biofilms.

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