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Silver cluster-biomolecule hybrids: from basics towards sensors.

Authors
  • Bonačić-Koutecký, Vlasta
  • Kulesza, Alexander
  • Gell, Lars
  • Mitrić, Roland
  • Antoine, Rodolphe
  • Bertorelle, Franck
  • Hamouda, Ramzi
  • Rayane, Driss
  • Broyer, Michel
  • Tabarin, Thibault
  • Dugourd, Philippe
Type
Published Article
Journal
Physical Chemistry Chemical Physics
Publisher
The Royal Society of Chemistry
Publication Date
Jul 14, 2012
Volume
14
Issue
26
Pages
9282–9290
Identifiers
DOI: 10.1039/c2cp00050d
PMID: 22414868
Source
Medline
License
Unknown

Abstract

We focus on the functional role of small silver clusters in model hybrid systems involving peptides in the context of a new generation of nanostructured materials for biosensing. The optical properties of hybrids in the gas phase and at support will be addressed with the aim to bridge fundamental and application aspects. We show that extension and enhancement of absorption of peptides can be achieved by small silver clusters due to the interaction of intense intracluster excitations with the π-π* excitations of chromophoric aminoacids. Moreover, we demonstrate that the binding of a peptide to a supported silver cluster can be detected by the optical fingerprint. This illustrates that supported silver clusters can serve as building blocks for biosensing materials. Moreover, the clusters can be used simultaneously to immobilize biomolecules and to increase the sensitivity of detection, thus replacing the standard use of organic dyes and providing label-free detection. Complementary to that, we show that protected silver clusters containing a cluster core and a shell liganded by thiolates exhibit absorption properties with intense transitions in the visible regime which are also suitable for biosensing applications.

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