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Silk Fibroin and Silk-Based Biomaterial Derivatives for Ideal Wound Dressings

Authors
  • Patil, Priyanka P.1
  • Reagan, Michaela R.2
  • Bohara, Raghvendra A3, 4
  • 1 Sigma Institute of Science and Commerce, Bakrol, Vadodara, Gujarat-390019
  • 2 Maine Medical Center Research Institute, Scarborough, Maine, USA 04106
  • 3 CÚRAM, SFI Research Centre for Medical Devices, National University of Ireland Galway, Ireland
  • 4 Centre for Interdisciplinary Research, D. Y. Patil University, Kolhapur-416006, India
Type
Published Article
Journal
International journal of biological macromolecules
Publication Date
Aug 16, 2020
Volume
164
Pages
4613–4627
Identifiers
DOI: 10.1016/j.ijbiomac.2020.08.041
PMID: 32814099
PMCID: PMC7849047
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Unknown

Abstract

Silk fibroin (SF) is derived from Bombyx mori silkworm cocoons and has been used in textiles and as a suture material for decades. More recently, SF has been used for various new biomedical applications, including as a wound dressing, owing to its excellent biological and mechanical properties. Specifically, the mechanical stiffness, versatility, biocompatibility, biodegradability, water vapor permeability and slight bactericidal properties make SF an excellent candidate biomaterial for wound dressing applications. The effectiveness of SF as a wound dressing has been tested and well documented invitro as well as invivo , as described here. Dressings based on SF are currently used for treating a wide variety of chronic and acute (eg. burn) wounds. SF and its derivatives prepared as biomaterials are available as sponges, hydrogels, nanofibrous matrices, scaffolds, micro/nanoparticles, and films. The present review discusses the potential role of SF in wound dressing and its modulation for wound dressing applications. The comparison of SF-based dressings with other natural polymers understands the readers, the scope and limitation of the subject in-depth.

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