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Silicone injection-induced granuloma formation, hypercalcemia and nephrolithiasis: a case report.

Authors
  • Ha, Albert S1
  • Chung, Rainjade1
  • Thorogood, Samantha2
  • Weiner, David M1
  • Shah, Ojas1
  • Healy, Kelly A1
  • 1 Department of Urology, Columbia University Irving Medical Center, New York, NY, USA.
  • 2 Department of Urology, Weill Cornell Medicine, New York, NY, USA.
Type
Published Article
Journal
Urology Case Reports
Publisher
Elsevier BV
Publication Date
May 01, 2021
Volume
36
Pages
101563–101563
Identifiers
DOI: 10.1016/j.eucr.2021.101563
PMID: 33489769
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Hypercalcemia and nephrolithiasis have been associated with various etiologies, including dysregulation of the parathyroid glands, malignancies, or sarcoidosis. Other causes of hypercalcemia, such as granulomatous disease resulting from silicone-based cosmetic injections, have been reported but without specific emphasis on nephrolithiasis. Herein, we report an unusual case of simultaneous bilateral obstructing ureteral calculi (SBUC) triggered by recalcitrant hypercalcemia and granulomatous disease due to silicone-based cosmetic injections. A careful surgical history, physical exam, and imaging identified the underlying etiology, which was confirmed by final histopathology. Using a multidisciplinary approach, the patient's condition was successfully managed with endoscopic procedures and concurrent corticosteroid therapy. © 2021 The Authors. Published by Elsevier Inc.

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