Affordable Access

Silicon compounds as stoichiometric coupling reagents for direct amidation

Authors
  • Davies, J
  • Braddock, D
  • Lickiss, P
Publication Date
Jul 18, 2021
Source
Spiral - Imperial College Digital Repository
Keywords
License
Green
External links

Abstract

Despite being one of the most frequently carried out chemical reactions in industry, there is currently no amidation protocol that is regarded as safe, high yielding, environmentally friendly and inexpensive. The direct amidation of a carboxylic acid with an amine is viewed as an inherently good solution for developing such a protocol. Since the 1960s, there has been a gradual development in the use of silicon reagents for direct amidation. This review covers the methods published to April 2021 for silicon reagent mediated direct amidation of a carboxylic acid with an amine. This review also covers the use of polymeric SiO2 to promote direct amidation.

Report this publication

Statistics

Seen <100 times