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In silico prediction of the granzyme B degradome.

Authors
  • Wee, Lawrence J K
  • Er, Esmond P S
  • Ng, Lisa F P
  • Tong, J C
Type
Published Article
Journal
BMC Genomics
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Nov 30, 2011
Volume
12 Suppl 3
Identifiers
PMID: 22479704
Source
Medline
License
Unknown

Abstract

We have compiled a comprehensive dataset of granzyme B cleavage sites and developed an accurate SVM-based prediction method utilizing Bayes Feature Extraction to identify novel substrates of granzyme B in silico. The prediction server is available online, together with reference datasets and supplementary materials.

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