Affordable Access

deepdyve-link
Publisher Website

In Silico Ocular Pharmacokinetic Modeling: Delivery of Topical FK962 to Retina.

Authors
  • Mori, Ayumi1
  • Yabuta, Chiho1
  • Kishimoto, Yayoi1
  • Kozai, Seiko1
  • Ohtori, Akira1
  • Shearer, Thomas R2
  • Azuma, Mitsuyoshi1, 2
  • 1 1 Senju Laboratory, Senju Pharmaceutical Co., Ltd. , Kobe, Japan . , (Japan)
  • 2 2 Department of Integrative Biosciences, Oregon Health & Science University , Portland, Oregon.
Type
Published Article
Journal
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
Publication Date
Sep 01, 2017
Volume
33
Issue
7
Pages
556–566
Identifiers
DOI: 10.1089/jop.2016.0136
PMID: 28598703
Source
Medline
Keywords
License
Unknown

Abstract

Our in silico model for ocular pharmacokinetics is useful (1) for predicting drug concentrations in specific ocular tissues after topical instillation, and (2) for suggesting the optimal dose regimens for eye drops. The pharmacodynamics for FK962 produced by this model may be useful for clinical trials against retinal neuropathy.

Report this publication

Statistics

Seen <100 times