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In silico drug screen in mouse liver identifies candidate calorie restriction mimetics.

Authors
  • Fortney, Kristen
  • Morgen, Eric K
  • Kotlyar, Max
  • Jurisica, Igor
Type
Published Article
Journal
Rejuvenation Research
Publisher
Mary Ann Liebert
Publication Date
Apr 01, 2012
Volume
15
Issue
2
Pages
148–152
Identifiers
DOI: 10.1089/rej.2011.1263
PMID: 22533420
Source
Medline
License
Unknown

Abstract

Calorie restriction (CR) extends life span in mammals and delays the onset of age-related diseases, including cancer and diabetes. Drugs that target the same genes and pathways as CR may have enormous therapeutic potential. Recently, genome-scale data on the responses of human cell lines to over 1,000 drug treatments have become available. Here we integrate these data with gene expression signatures of CR in mouse liver to generate a prioritized list of candidate CR mimetics. We identify 14 drugs that reproduce the effects of CR at the transcriptional level.

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