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Silencing of the XAF1 gene by promoter hypermethylation in cancer cells and reactivation to TRAIL-sensitization by IFN-beta.

Authors
  • Micali, O Cristina
  • Cheung, Herman H
  • Plenchette, Stéphanie
  • Hurley, Sandra L
  • Liston, Peter
  • LaCasse, Eric C
  • Korneluk, Robert G
Type
Published Article
Journal
BMC Cancer
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jan 01, 2007
Volume
7
Pages
52–52
Identifiers
PMID: 17376236
Source
Medline
License
Unknown

Abstract

Together, these results suggest that promoter demethylation is not the sole factor determining xaf1 gene induction under IFN-beta treatment. Furthermore, our study provides evidence that XAF1 is a crucial interferon-stimulated gene (ISG) mediator of IFN-induced sensitization to TRAIL in cancer.

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