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Silencing microRNA-181a-5p suppresses malignant behavior of lacrimal adenoid cystic carcinoma cells by upregulating large tumor suppressor 2

Authors
  • Fu, Rongrong
  • Wang, Yingshuang
  • Wang, Yawen
Type
Published Article
Journal
International journal of clinical and experimental pathology
Publication Date
Sep 01, 2020
Volume
13
Issue
9
Pages
2419–2426
Identifiers
PMID: 33042355
PMCID: PMC7539885
Source
PubMed Central
Keywords
License
Unknown

Abstract

To uncover the effect of miR-181a-5p regulating large tumor suppressor 2 (LATS2) in biologic processes of adenoid cystic carcinoma (ACC) cells, miR-181a-5p and LATS2 expression in lacrimal ACC (LACC) tissues were assessed. The ACC cell lines were respectively treated with altered miR-181a-5p or LATS2 to determine the biologic functions in ACC cells. Binding ability of miR-181a-5p and LATS2 was confirmed. Tumor growth in vivo was assessed as well. MiR-181a-5p was upregulated while LATS2 was downregulated in LACC tissues. Reduced miR-181a-5p restrained malignant phenotype of ACC cells and decelerated xenograft growth. Conversely, LATS2 reduction had opposite effects compared to miR-181a-5p knockdown on ACC cells. Furthermore, downregulated LATS2 could abolish the alterations in ACC cells induced by miR-181a-5p silencing. MiR-181a-5p inhibition upregulated LATS2 to suppress malignant behavior of ACC cells in vivo and in vitro .

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