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Significant role of host sialylated glycans in the infection and spread of severe acute respiratory syndrome coronavirus 2

Authors
  • Saso, Wakana
  • Yamasaki, Masako
  • Nakakita, Shin-ichi
  • Fukushi, Shuetsu
  • Tsuchimoto, Kana
  • Watanabe, Noriyuki
  • Sriwilaijaroen, Nongluk
  • Kanie, Osamu
  • Muramatsu, Masamichi
  • Takahashi, Yoshimasa
  • Matano, Tetsuro
  • Takeda, Makoto
  • Suzuki, Yasuo
  • Watashi, Koichi
Type
Published Article
Journal
PLoS Pathogens
Publisher
Public Library of Science
Publication Date
Jun 14, 2022
Volume
18
Issue
6
Identifiers
DOI: 10.1371/journal.ppat.1010590
PMID: 35700214
PMCID: PMC9197039
Source
PubMed Central
Disciplines
  • Biology and Life Sciences
  • Microbiology
  • Virology
  • Viral Transmission and Infection
  • Viral Entry
License
Unknown

Abstract

SARS-CoV-2, which has been highly transmissible and rapidly spreading worldwide, has caused approximately 458 million confirmed cases of COVID-19 with more than 6 million deaths by March 2022. Here we found that SARS-CoV-2 infection was significantly inhibited by α2-6-linked sialic acid-containing compounds and by depletion of cell surface sialic acid with only a minor effect on SARS-CoV infection. We identified that SARS-CoV-2 spike S1 subunit directly binds to α2-6-linked sialoglycans for efficient attachment to host cell surface. Our finding indicated that host sialoglycans play a significant role in the efficient infection of SARS-CoV-2, which provides a novel understanding of the molecular basis explaining the rapid spread of SARS-CoV-2 over SARS-CoV.

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