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Significance and Role of Pattern Recognition Receptors in Malignancy

Authors
  • Żeromski, Jan1
  • Kaczmarek, Mariusz1
  • Boruczkowski, Maciej1
  • Kierepa, Agata2
  • Kowala-Piaskowska, Arleta2
  • Mozer-Lisewska, Iwona2
  • 1 Karol Marcinkowski University of Medical Sciences, Department of Clinical Immunology, Poznań, Poland , Poznań (Poland)
  • 2 Karol Marcinkowski University of Medical Sciences, Department of Infectious Diseases, Hepatology and Acquired Immunodeficiencies, Poznań, Poland , Poznań (Poland)
Type
Published Article
Journal
Archivum Immunologiae et Therapiae Experimentalis
Publisher
Springer-Verlag
Publication Date
Apr 11, 2019
Volume
67
Issue
3
Pages
133–141
Identifiers
DOI: 10.1007/s00005-019-00540-x
Source
Springer Nature
Keywords
License
Green

Abstract

Pattern recognition receptors (PRRs) are members of innate immunity, playing pivotal role in several immunological reactions. They are known to act as a bridge between innate and adaptive immunity. They are expressed on several normal cell types but have been shown with increasing frequency on/in tumor cells. Significance of this phenomenon is largely unknown, but it has been shown by several authors that they, predominantly Toll-like receptors (TLRs), act in the interest of tumor, by promotion of its growth and spreading. Preparation of artificial of TLRs ligands (agonists) paved the way to use them as a therapeutic agents for cancer, so far in a limited scale. Agonists may be combined with conventional anti-cancer modalities with apparently promising results. PRRs recognizing nucleic acids such as RIG-1 like receptors (sensing RNA) and STING (sensing DNA) constitute a novel promising approach for cancer immunotherapy.

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