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The significance of genetics in pathophysiologic models of premature birth.

Authors
  • Uberos, Jose1
  • 1 Neonatal Unit, Hospital Clínico San Cecilio, Granada, Spain - [email protected] , (Spain)
Type
Published Article
Journal
Minerva pediatrica
Publication Date
May 31, 2017
Identifiers
DOI: 10.23736/S0026-4946.17.04994-5
PMID: 28565902
Source
Medline
License
Unknown

Abstract

Prematurity is a major health problem in all countries, especially in certain ethic groups and increasing recurrence imply the influence of genetic factors. Published genetic polymorphisms are identified in relation to the 4 pathophysiological models of prematurity described: Chorioamniotic-decidual inflammation, premature contraction pathway, decidual haemorrhage and susceptibility to environmental toxins. 240 articles are identified, 52 articles are excluded because they are not original, not written in English or duplicated. From them 125 articles were included in qualitative analysis This review aims to update recent knowledge about genes associated with premature birth.

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