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[Significance of efflux pumps in multidrug resistance of Gram-negative bacteria].

Authors
  • Wiercińska, Olga
  • Chojecka, Agnieszka
  • Kanclerski, Krzysztof
  • Rőhm-Rodowald, Ewa
  • Jakimiak, Bożenna
Type
Published Article
Journal
Medycyna doświadczalna i mikrobiologia
Publication Date
Jan 01, 2015
Volume
67
Issue
1
Pages
55–62
Identifiers
PMID: 26084076
Source
Medline
License
Unknown

Abstract

The phenomenon of multidrug. resistance of bacteria is a serious problem of modern medicine. This resistance largely is a consequence of abuse and improper use of antibacterial substances, especially antibiotics and chemotherapeutics in hospital settings. Multidrug resistance is caused by a number of interacting mechanisms of resistance. Recent studies have indicated that efflux pumps and systems of efflux pumps are an important determinant of this phenomenon. Contribute to this particular RND efflux systems of Gram-negative bacteria, which possess a wide range of substrates such as antibiotics, dyes, detergents, toxins and active substances of disinfectants and antiseptics. These transporters are usually encoded on bacterial chromosomes. Genes encoding efflux pumps' proteins may also be carried on plasmids and other mobile genetic elements. Such pumps are usually specific to a small group of substrates, but as an additional mechanism of resistance may contribute to the multidrug resistance.

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