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Signalling mechanisms underlying subversion of the immune response by the filarial nematode secreted product ES-62

Authors
  • Helen S Goodridge
  • Gillian Stepek
  • William Harnett
  • Margaret M Harnett
Publisher
Blackwell Science Inc
Publication Date
Jul 01, 2005
Source
PMC
Keywords
Disciplines
  • Biology
License
Unknown

Abstract

Secretion of immunomodulatory molecules is a key strategy employed by pathogens to enable their survival in host organisms. For example, arthropod-transmitted filarial nematodes, which achieve longevity within the infected host by suppressing and modulating the host immune response, produce excretory–secretory (ES) products that have been demonstrated to possess immunomodulatory properties. In this review we discuss the immunomodulatory effects of the phosphorylcholine-containing filarial nematode-secreted glycoprotein ES-62 and describe the intracellular signal transduction pathways it targets to achieve these effects.

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