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A signal-flexible gene diagnostic strategy coupling loop-mediated isothermal amplification with hybridization chain reaction

Authors
  • Dong, Qing1, 2
  • Liu, Quanyi1, 3
  • Guo, Lulu1, 3
  • Li, Dan1
  • Shang, Xudong1, 3
  • Li, Bingling1, 3
  • Du, Yan1, 3
  • 1 State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China
  • 2 Changchun University of Science and Technology, Changchun, Jilin, 130022, China
  • 3 Department of Chemistry, University of Science & Technology of China, Hefei, Anhui, 230026, China
Type
Published Article
Journal
Analytica chimica acta
Publication Date
Jun 29, 2019
Volume
1079
Pages
171–179
Identifiers
DOI: 10.1016/j.aca.2019.06.048
PMID: 31387708
PMCID: PMC7094597
Source
PubMed Central
Keywords
License
Unknown

Abstract

• Highly sensitive and selective detection method for norovirus gene. • Sensitivity down to 30 gene copies in 2% fecal samples. • Significantly enlarged signal change and signal-to-background ratio. • Higher tolerance capability to complicated biological matrices. • Exhibiting great potential to be used in the diagnosis of gastroenteritis in hospital or at home.

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