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Signal transduction in neurons: effects of cellular prion protein on fyn kinase and ERK1/2 kinase.

Authors
  • Tomasi, Vittorio
Type
Published Article
Journal
Immunity & ageing : I & A
Publication Date
Jan 01, 2010
Volume
7 Suppl 1
Identifiers
DOI: 10.1186/1742-4933-7-S1-S5
PMID: 21172064
Source
Medline
License
Unknown

Abstract

We observed that, after antibody-mediated cross-linking or copper treatment, PrPc was internalized probably into caveolae. We propose that following translocation from rafts to caveolae or caveolae-like domains, secPrP could interact with caveolin-1 and induce signal transduction events.

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