We observed that, after antibody-mediated cross-linking or copper treatment, PrPc was internalized probably into caveolae. We propose that following translocation from rafts to caveolae or caveolae-like domains, secPrP could interact with caveolin-1 and induce signal transduction events.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/21172064