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The side effects of antimalarial drugs indicates a polyamine involvement in both schizophrenia and depression.

Authors
  • Andrews, R C
Type
Published Article
Journal
Medical Hypotheses
Publisher
Elsevier
Publication Date
Sep 01, 1985
Volume
18
Issue
1
Pages
11–18
Identifiers
PMID: 4069032
Source
Medline
License
Unknown

Abstract

The nature of the side effects produced by the antimalarials and a common moiety present in these drugs (spermidine) links the polyamines to both schizophrenia and depression. The raised incidence of psychosis in systemic lupus erythematosus and during pregnancy both associated with raised blood polyamine levels, makes the involvement of the polyamines in psychosis more likely.

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