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Sickle cell disease in areas of immigration of high-risk populations: a low cost and reproducible method of screening in northern Italy.

Authors
  • Venturelli, Donatella
  • Lodi, Mariachiara
  • Palazzi, Giovanni
  • Bergonzini, Giuliano
  • Doretto, Giada
  • Zini, Annalisa
  • Monica, Cellini
  • Cano, M Carmen
  • Ilaria, Mariotti
  • Montagnani, Giuliano
  • Paolucci, Paolo
Type
Published Article
Journal
Blood transfusion = Trasfusione del sangue
Publication Date
Jul 01, 2014
Volume
12
Issue
3
Pages
346–351
Identifiers
DOI: 10.2450/2013.0188-13
PMID: 24887233
Source
Medline
License
Unknown

Abstract

These results support the feasibility and usefulness of a selective screening for the detection of haemoglobin variants in high-risk subjects in an area in which sickle cells disease is not endogenous. We achieved the goal of detecting subjects with carrier trait/disease in order to implement preventive measures that reduce the clinical manifestations of sickle cell disease. We are, however, aware that it will be necessary to extend this screening to the overall population in the near future.

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