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Sickle cell biomechanics.

Authors
  • Barabino, Gilda A
  • Platt, Manu O
  • Kaul, Dhananjay K
Type
Published Article
Journal
Annual review of biomedical engineering
Publication Date
Aug 15, 2010
Volume
12
Pages
345–367
Identifiers
DOI: 10.1146/annurev-bioeng-070909-105339
PMID: 20455701
Source
Medline
License
Unknown

Abstract

As the predominant cell type in blood, red blood cells (RBCs) and their biomechanical properties largely determine the rheological and hemodynamic behavior of blood in normal and disease states. In sickle cell disease (SCD), mechanically fragile, poorly deformable RBCs contribute to impaired blood flow and other pathophysiological aspects of the disease. The major underlying cause of this altered blood rheology and hemodynamics is hemoglobin S (HbS) polymerization and RBC sickling under deoxygenated conditions. This review discusses the characterization of the biomechanical properties of sickle RBCs and sickle blood as well as their implications toward a better understanding of the pathophysiology of the disease.

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