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Sialyltransferases in cancer.

Authors
  • Dall'Olio, F
  • Chiricolo, M
Type
Published Article
Journal
Glycoconjugate journal
Publication Date
Jan 01, 2001
Volume
18
Issue
11-12
Pages
841–850
Identifiers
PMID: 12820717
Source
Medline
License
Unknown

Abstract

It has long been known that cancer cells often express more heavily sialylated glycans on their surface and that this feature sometimes correlates with invasion. It is now well established that specific sialylated structures, such as the Thomsen-Friedenreich-related antigens, the sialyl Lewis antigens, the sialyl alpha2-6 lactosaminyl structure, the polysialic acid or some gangliosides, can mediate cellular interactions and are altered in cancer cells. This review summarizes the current knowledge on the cancer-associated alterations in sialyltransferase expression which are often at the basis of the deranged expression of sialylated structures.

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