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Sialoadhesin in recognition of self and non-self.

Authors
  • Klaas, Mariliis
  • Crocker, Paul R
Type
Published Article
Journal
Seminars in immunopathology
Publication Date
May 01, 2012
Volume
34
Issue
3
Pages
353–364
Identifiers
DOI: 10.1007/s00281-012-0310-3
PMID: 22450957
Source
Medline
License
Unknown

Abstract

The immune system is tightly regulated to maintain an appropriate balance between immune activation and tolerance. Macrophages play a key role in this process since they express many pathogen recognition molecules as well as receptors for 'self'. Sialoadhesin is a major macrophage receptor that specifically recognizes sialic acid, an abundant component of host glycoconjugates but which can also be found on several human pathogens. In recent years, several studies have demonstrated that sialoadhesin can contribute to the uptake and processing of sialylated pathogens as well as playing an important role in regulating inflammatory and autoimmune responses via recognition of self.

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