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Sialic acid metabolism as a potential therapeutic target of atherosclerosis

Authors
  • Zhang, Chao1, 2
  • Chen, Jingyuan1
  • Liu, Yuhao1
  • Xu, Danyan1
  • 1 Central South University, Department of Cardiovascular Medicine, The Second Xiangya Hospital, 139 Middle Renmin Road, Changsha, Hunan, 410011, China , Changsha (China)
  • 2 Hunan Provincial People’s Hospital, Department of Health Management Center, 61 Jiefang West Road, Changsha, Hunan, 410005, China , Changsha (China)
Type
Published Article
Journal
Lipids in Health and Disease
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Sep 14, 2019
Volume
18
Issue
1
Identifiers
DOI: 10.1186/s12944-019-1113-5
Source
Springer Nature
Keywords
License
Green

Abstract

Sialic acid (Sia), the acylated derivative of the nine-carbon sugar neuraminic acid, is a terminal component of the oligosaccharide chains of many glycoproteins and glycolipids. In light of its important biological and pathological functions, the relationship between Sia and coronary artery disease (CAD) has been drawing great attentions recently. Large-scale epidemiological surveys have uncovered a positive correlation between plasma total Sia and CAD risk. Further research demonstrated that N-Acetyl-Neuraminic Acid, acting as a signaling molecule, triggered myocardial injury via activation of Rho/ROCK-JNK/ERK signaling pathway both in vitro and in vivo. Moreover, there were some evidences showing that the aberrant sialylation of low-density lipoprotein, low-density lipoprotein receptor and blood cells was involved in the pathological process of atherosclerosis. Significantly, the Sia regulates immune response by binding to sialic acid-binding immunoglobulin-like lectin (Siglecs). The Sia-Siglecs axis is involved in the immune inflammation of atherosclerosis. The generation of Sia and sialylation of glycoconjugate both depend on many enzymes, such as sialidase, sialyltransferase and trans-sialidase. Abnormal activation or level of these enzymes associated with atherosclerosis, and inhibitors of them might be new CAD treatments. In this review, we focus on summarizing current understanding of Sia metabolism and of its relevance to atherosclerosis.

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